Opportunity Information: Apply for RFA CA 21 019
This grant opportunity, RFA-CA-21-019, is a National Institutes of Health (NIH) National Cancer Institute (NCI) funding announcement designed specifically for revision applications to existing NCI-funded U24 cooperative agreement projects. In other words, it is not meant for brand-new standalone projects; it targets teams that already hold an active NCI U24 award for a resource-related research project and want to expand what they are already doing. The central idea is to broaden the scope of the parent U24 by bringing in informatics methods, tools, or resources that were created through the NCI Informatics Technology for Cancer Research (ITCR) Program, whether that ITCR support is current or in the past. The overall goal is to accelerate cancer research by getting proven or promising ITCR-developed technologies more widely adopted, adapted, and integrated into established NCI research resources.
The purpose of the revisions funded through this FOA is to stimulate new collaborations and practical technology uptake across cancer research communities. Rather than supporting informatics development in isolation, the announcement emphasizes real-world application: applicants are expected to incorporate ITCR-derived tools into the workflows, platforms, datasets, or services of their existing U24 resources. This could include integrating software, data standards, analytic pipelines, or other informatics capabilities into an operational resource that already serves researchers. By doing this under the umbrella of a revision to a currently funded project, NCI is trying to reduce barriers to adoption and encourage interdisciplinary teams that combine domain science expertise with informatics implementation experience.
Mechanistically, the award uses a cooperative agreement (U24), which typically means NIH/NCI will have substantial programmatic involvement compared with a standard grant. The clinical trial designation is "Clinical Trial Optional," meaning proposed activities may include a clinical trial if appropriate, but a clinical trial is not required for eligibility under the announcement. The funding instrument supports discretionary awards within NIH's health and education-related activities, and it is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, and 93.399), reflecting alignment with several NCI funding authorities and program areas.
In terms of who can apply, eligibility is broad and includes many common research and public-interest entities: public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses) as well as small businesses, and a range of governmental bodies (state, county, city/township, and special district governments). It also includes federally recognized Native American tribal governments and other tribal organizations, plus public housing authorities and other applicants as clarified in the FOA text. Even with this wide eligibility, the key practical gate is that applicants must be positioned to submit a revision to an existing NCI U24 resource-related research award, since the FOA is explicitly focused on revisions rather than new awards.
Financially, the announcement lists an award ceiling of $100,000 and anticipates making about four awards. That ceiling suggests these are intended to be focused, targeted expansions to ongoing work rather than large multi-year buildouts. The expectation is that the added funds will directly enable the incorporation and demonstration of ITCR-derived informatics capabilities in a way that benefits the relevant research communities tied to the U24 resource.
Timing details included in the source indicate the FOA was created on December 2, 2020, with an original closing date of November 18, 2021. The sponsoring agency is the U.S. Department of Health and Human Services through NIH, specifically NCI. Overall, the opportunity is best understood as a bridge between ITCR-funded innovation and the broader cancer research ecosystem: it provides modest, strategic funding to help existing NCI U24 resources integrate and operationalize informatics technologies so they can be used, tested, and improved in real scientific settings, ultimately aiming to speed discovery and increase the impact of prior federal investments in cancer informatics.Apply for RFA CA 21 019
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Dec 02, 2020.
- Applicants must submit their applications by Nov 18, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Proteogenomic Data Analysis Centers (PGDACs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 024 Funding Number: RFA CA 21 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
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| Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 023 Funding Number: RFA CA 21 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 21 037 Funding Number: RFA CA 21 037 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
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