Opportunity Information: Apply for RFA HG 24 001
The National Institutes of Health (NIH), through the National Human Genome Research Institute (NHGRI), is soliciting applications under funding opportunity RFA-HG-24-001 to create a small Genomic Medicine eConsult Research Network. This program will fund 2 to 3 participating sites under a U01 cooperative agreement to study both the real-world impact and the practical implementation of regional clinician-to-clinician genomic medicine eConsult services. In this context, an eConsult service is a structured way for a clinician to request guidance from genomic medicine experts (or a specialized team) to support patient care decisions, particularly when local expertise is limited.
The central focus is implementation research: sites are expected to investigate how to best design, develop, and roll out regional genomic medicine eConsult programs in ways that work across diverse clinical settings. This includes figuring out the service model, workflows, staffing and expertise needs, intake and triage processes, response formats, and how the eConsult integrates into routine clinical care. A major emphasis is also placed on outreach and engagement, meaning applicants should plan how they will raise awareness and drive adoption among potential users, including clinicians practicing in underserved settings where access to genetics/genomics specialists may be constrained.
In addition to building and operating the regional eConsult approach, funded sites must evaluate its impact on key stakeholders. That typically implies assessing outcomes for referring clinicians (such as changes in confidence, knowledge, decision-making, or time-to-answer), specialists and consult teams (such as workload and feasibility), health systems (such as workflow efficiency and potential cost implications), and patients (such as access to appropriate testing, interpretation of results, follow-up recommendations, and equity-related effects). The NOFO also highlights the expectation that awardees will generate practical implementation strategies and reusable resources that can be shared broadly, so that other health systems and regions can adopt proven approaches rather than starting from scratch.
Because this is a cooperative agreement (U01), NHGRI will have an active partnership role rather than serving only as a funder. In practice, that usually means the funded sites will work closely with NHGRI and with each other as a coordinated network, aligning on common research questions where appropriate, collaborating on methods, and contributing to shared deliverables that strengthen generalizability and dissemination. Clinical trials are optional under this announcement, meaning applicants may include a clinical trial component if it is justified by the research aims, but they are not required to do so.
Eligible applicants are broad and include many types of U.S.-based organizations and governments: state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The NOFO also explicitly calls out additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. However, foreign organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Key administrative details provided include the opportunity category (discretionary), the activity area (health), and the CFDA/assistance listing number 93.172. The original application due date listed is May 30, 2024, and the opportunity was created on January 9, 2024. The award ceiling and expected award amounts are not specified in the provided text, but the overall structure indicates a limited number of awards intended to stand up a small, tightly coordinated research network focused on scalable, equity-aware implementation of genomic medicine eConsult services at a regional level.Apply for RFA HG 24 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on the Impact of and Methods for Implementing Regional Genomic Medicine eConsult Services (U01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2024-01-09.
- Applicants must submit their applications by 2024-05-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: RFA-HG-24-001 Genomic Medicine eConsult Research Network (NHGRI/NIH)
1. What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity from the National Human Genome Research Institute (NHGRI) under RFA-HG-24-001 to create a small Genomic Medicine eConsult Research Network. Funded sites will study the real-world impact and practical implementation of regional clinician-to-clinician genomic medicine eConsult services.
2. What is the goal of the Genomic Medicine eConsult Research Network?
The goal is to fund a small, coordinated network of sites that can design, develop, implement, and evaluate regional genomic medicine eConsult programs, with an emphasis on scalable and equity-aware implementation approaches that can be shared and reused by other systems and regions.
3. How many awards will be made?
NHGRI expects to fund 2 to 3 participating sites under this opportunity.
4. What award mechanism will be used?
Funding will be provided through a U01 cooperative agreement.
5. What does a U01 cooperative agreement mean for awardees?
Because this is a cooperative agreement, NHGRI will have an active partnership role rather than acting only as a funder. Awardees are expected to work closely with NHGRI and with each other as a coordinated network, align on common research questions where appropriate, collaborate on methods, and contribute to shared deliverables that support generalizability and dissemination.
6. What is a genomic medicine eConsult in this program?
In this context, an eConsult service is a structured way for a clinician to request guidance from genomic medicine experts (or a specialized team) to support patient care decisions, particularly when local genetics/genomics expertise is limited.
7. What is the primary research focus of this NOFO?
The central focus is implementation research. Sites are expected to study how best to design, develop, and roll out regional genomic medicine eConsult programs across diverse clinical settings.
8. What implementation topics are sites expected to address?
Based on the information provided, implementation research may include topics such as the eConsult service model, workflows, staffing and expertise needs, intake and triage processes, response formats, and how eConsults integrate into routine clinical care.
9. Is outreach and engagement part of the expected work?
Yes. The opportunity places major emphasis on outreach and engagement. Applicants are expected to plan how they will raise awareness and drive adoption among potential users, including clinicians in underserved settings where access to genetics/genomics specialists may be constrained.
10. What types of outcomes or impacts should funded sites evaluate?
Funded sites are expected to evaluate the impact of the regional eConsult approach on key stakeholders. Examples described include outcomes for referring clinicians, specialists/consult teams, health systems, and patients, including equity-related effects.
11. What impacts for referring clinicians are mentioned?
Examples include changes in clinician confidence, knowledge, decision-making, or time-to-answer after using the genomic medicine eConsult service.
12. What impacts for specialists or consult teams are mentioned?
Examples include workload and feasibility considerations for the specialists or specialized consult teams providing eConsult guidance.
13. What impacts for health systems are mentioned?
Examples include workflow efficiency and potential cost implications associated with implementing and operating a regional genomic medicine eConsult service.
14. What impacts for patients are mentioned?
Examples include access to appropriate testing, interpretation of results, follow-up recommendations, and equity-related effects tied to the eConsult-enabled care pathway.
15. Are awardees expected to create shareable resources?
Yes. The NOFO highlights an expectation that awardees will generate practical implementation strategies and reusable resources that can be shared broadly so other health systems and regions can adopt proven approaches.
16. Do proposed projects need to include clinical trials?
No. Clinical trials are optional under this announcement. Applicants may include a clinical trial component if justified by the research aims, but a clinical trial is not required.
17. Who is eligible to apply?
Eligible applicants are broad and include many U.S.-based organizations and governments. Examples listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses.
18. Are there additional eligible organization categories explicitly called out?
Yes. Additional eligible categories explicitly called out include Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
19. Are foreign organizations eligible to apply?
No. Foreign organizations are not eligible to apply under this opportunity.
20. Are non-U.S. components of U.S. organizations allowed?
No. Non-U.S. components of U.S. organizations are not eligible.
21. Are foreign components allowed (per NIH policy definitions)?
No. Foreign components (as defined by NIH policy) are not allowed under this opportunity.
22. What is the opportunity category and activity area?
The opportunity category is discretionary and the activity area is health.
23. What is the Assistance Listing (CFDA) number for this opportunity?
The CFDA/Assistance Listing number provided is 93.172.
24. What is the application due date listed in the provided information?
The original application due date listed is May 30, 2024.
25. When was this opportunity created?
The opportunity was created on January 9, 2024.
26. Is the award ceiling or expected award amount provided?
No. The award ceiling and expected award amounts are not specified in the provided information.
27. What kind of network structure is implied by the NOFO?
The information provided describes a limited number of awards intended to stand up a small, tightly coordinated research network. The network is expected to work collaboratively with NHGRI and across sites to support shared learning, common methods where appropriate, and dissemination of broadly reusable implementation approaches.
28. What is meant by "regional" genomic medicine eConsult services in this context?
The provided description emphasizes designing and implementing clinician-to-clinician genomic medicine eConsult services that operate across diverse clinical settings and support clinicians who may not have local genomics expertise available, including those in underserved settings.
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